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目的：研究糖尿病视网膜病变（ DR）患者的脑组织损伤。方法选取合并视网膜病变的2型糖尿病患者27例（ DM组）以及健康对照组24例（ HC组），所有研究对象行氢质子磁共振波谱（1 H-MRS ）以及扩散加权成像（ DWI）检查。感兴趣区域（ ROIs）定位于颅脑左侧额叶白质、左侧豆状核以及左侧视辐射区。计算ROIs内N-乙酰天门冬氨酸（ NAA）/肌酸（ Cr）、胆碱化合物（ Cho）/肌酸（ Cr）、肌醇（ MI）/Cr以及NAA/Cho值，并测量表观扩散系数（ADC）。结果 DM组额叶白质NAA/Cr、NAA/Cho值均低于HC组（P＜0．05），豆状核NAA/Cr值低于HC组（P＜0．05）；视辐射区NAA/Cho值低于HC组，MI/Cr值高于HC组（P＜0．05）。 DM组额叶白质NAA/Cr值与糖化血红蛋白（HbA1c）水平呈负相关（r＝-0．652，P＜0．05），视辐射区MI/Cr与Cho/Cr值呈正相关（r＝0．520， P＜0．05）。 DM组所有ROIs内ADC值均高于HC组（P＜0．05）。结论糖尿病视网膜病变患者存在早期脑组织损伤，临床医师应采取干预措施，预防严重的脑血管疾病的发生。“,”Objective To investigate the brain damage in patients with diabetic retinopathy ( DR) .Methods Twenty-seven type 2 diabetes mellitus ( T2DM) patients with retinopathy ( DM group) and twenty-four healthy controls ( HC group) were selected.Proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted imaging (DWI) were performed on all the participants.Regions of interest ( ROIs) were located in the left frontal white matter, left len-ticular nucleus, and left optic radiation.N-acetylaspartate ( NAA)/creatine ( Cr), Choline ( Cho)/creatine ( Cr), myo-inositol ( MI)/Cr, and NAA/Cho ratios and ADC values of all the ROIs were obtained.Results In the frontal white matter, NAA/Cr and NAA/Cho ratios were lower in the DM group than in the HC group (P<0.05).In the len-ticular nucleus, NAA/Cr ratios were lower in the DM group than in the HC group (P<0.05).In the optic radiation, NAA/Cho ratios in the DM group were decreased, while MI/Cr values were increased compared with those in the HC group (P<0.05).In the DM group, NAA/Cr ratios in the frontal white matter were negatively correlated with glycosy-lated hemoglobin (HbA1C) levels (r=-0.652, P<0.05).In the optic radiation, MI/Cr ratios were positively correlatedwith Cho/Cr values (r=0.520, P<0.05) in the DM group.ADC values in the DM group were significantly higher than those in the HC group (P<0.05).Conclusion Patients with DR are accompanied with early brain injury and cli-nicians should take measures to prevent the occurrence of severe cerebrovascular diseases.