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本文报道普罗帕酮(propafenone)致严重心血管不良反应8例。静脉注射普罗帕酮7例中,显著血压下降者6例;窦房结功能抑制3例;急性左心衰竭2例;心房扑动患者静脉给药后,心房扑动变为1:1传导,心室率显著加快1例;另1例心房扑动患者,口服普罗帕酮600mg/d,9d后发生完全性房室传导阻滞,呈缓慢室性自搏性心律伴显著血压下降。作者推荐先用最低有效量,逐渐加量,特别对左室功能受损,窦房结功能不全和有传导障碍者,尤须谨慎。
This article reports the propofenone (propafenone) induced serious adverse cardiovascular reactions in 8 cases. Intravenous propafenone in 7 cases, significant decreased blood pressure in 6 cases; sinus node function was inhibited in 3 cases; acute left heart failure in 2 cases; atrial flutter patients after intravenous administration, atrial flutter into a 1: 1 conduction, Ventricular rate was significantly accelerated in 1 case; the other 1 patient with atrial flutter, oral propafenone 600mg / d, 9 days after a complete atrioventricular block, was slow ventricular spontaneous cardiac rhythm with significant drop in blood pressure. The authors recommend the first with the minimum effective dose, gradually increase the amount, especially for left ventricular dysfunction, sinus node dysfunction and conduction disorders, especially cautious.