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人类卵泡由始基卵泡发育成成熟卵泡,根据其不同变化,可以分成四个阶段:在开始时主要是卵母细胞的生长、发育,并在其周围形成透明带,继之在粒层细胞上出现明显的形态与生化结构的变化;形成FSH-R、类固醇激素受体、裂隙联接与卵泡内膜等;随着卵泡的继续发育、卵泡液出现,LH-R,PRL-R等形成;在FSH诱导下芳香化酶出现活性,从而形成局部激素微环境,在全身与局部激素的调节下,进一步发育成排卵前卵泡,成熟并排卵。本文对卵泡整个发育过程作扼要介绍。
Human follicles develop from primordial follicles into mature follicles, which can be divided into four stages according to their different changes: at the outset they are primarily oocyte growth, development and formation of zona pellucida around them, followed by dissection on granulosa cells The formation of FSH-R, steroid hormone receptor, fissure connection and follicular intima; with the continued development of follicles, follicular fluid, LH-R, PRL-R and other forms; in the FSH-induced aromatase activity, resulting in the formation of local hormone microenvironment, the regulation of systemic and local hormones, further development into anovulatory follicles, mature and ovulation. This article gives a brief introduction of the whole process of follicular development.