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目的观察胸腔热灌康莱特治疗恶性肿瘤合并胸水的疗效及毒副反应。方法选取本院住院恶性肿瘤胸水(腺癌)患者63例行胸腔深静脉置管术,并随机分为两组,实验组33例经导管灌注42℃~45℃生理盐水行反复胸腔内热灌洗2次,最后1次抽净灌洗液后,经导管胸腔内灌注康莱特注射液;对照组30例灌注常温康莱特注射液。结果治疗组临床总有效率达87.9%,对照组总有效率为60.0%,差异有显著性(P<0.05),实验组Karnofsky标准评分与对照组比较差异有显著性(P<0.01)。实验组不良反应发生率30.3%,对照组30.0%,差异无显著性。结论胸腔热灌注康莱特可明显提高恶性胸水患者的治疗效果,是一种安全有效的方法。
Objective To observe the curative effect and side effects of pleural fluid heat irrigation Kanglaite on malignant tumor with pleural effusion. Methods Sixty-three patients with malignant pleural effusion (adenocarcinoma) in our hospital were treated by deep-seated thoracic vein and were randomly divided into two groups. In the experimental group, 33 patients underwent catheterization of 42 ℃ -45 ℃ saline through repeated catheterization 2 times, after the last pumping net irrigation fluid, intracranial infusion of Kanglaite injection catheter; control group of 30 patients perfusion Kanglaite injection at room temperature. Results The total clinical effective rate was 87.9% in the treatment group and 60.0% in the control group, with significant difference (P <0.05). The Karnofsky standard score in the experimental group was significantly lower than that in the control group (P <0.01). The incidence of adverse reactions in the experimental group 30.3%, 30.0% in the control group, the difference was not significant. Conclusion Pleural perfusion of Kanglaite can significantly improve the treatment of patients with malignant pleural effusion, is a safe and effective method.