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十多年前Brown和Pedersen从猪小肠粘膜提取出一种由43个氨基酸组成的多肽,观察到这种多肽能抑制狗海氏小胃的胃酸分泌,并设想抑制胃酸分泌可能是此种多肽的主要生理作用,因此将它命名为“抑胃多肽”(gastric inhibitory polypeptide,GIP)。但在人体内生理剂量的GIP是否有抑制胃酸分泌作用尚未有定论。最近美国Maxwell等在8个男性受试者静脉滴注五肽胃泌素引起胃液分泌,其剂量从25至74、222、667和2000ng/公斤/小时逐级增加,每种剂量维持30分钟。在另外的实验日还加用GIP 2μg/公斤/小时静脉滴注。结果表明,GIP只抑制剂量为222ng/公斤/小时的五肽胃泌素引起的胃酸分泌,而对其它剂量
More than a decade ago, Brown and Pedersen extracted a polypeptide of 43 amino acids from porcine intestinal mucosa and observed that this polypeptide inhibits gastric acid secretion in the dog’s stomach and suppresses gastric acid secretion which may be the result of this polypeptide Its main physiological role, therefore, it is named “gastric inhibitory polypeptide” (GIP). However, the physiological dose of GIP in the human body whether gastric acid secretion inhibition has not yet been conclusive. Recently, the United States Maxwell et al intravenous pentagastrin in eight male subjects caused gastric secretion, the dose increased from 25 to 74,222,667 and 2000ng / kg / hour step by step, each dose for 30 minutes. Additional GIP 2μg / kg / hr IV infusion was also added on additional experimental days. The results showed that GIP only inhibited pentagastrin-induced gastric acid secretion at a dose of 222 ng / kg / hr, whereas for other doses