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美国国立癌症研究所(NCI)正开始使用一种新的组织培养筛选系统。希望该系统能对该所每年进行的几千种化合物的筛选提供快速有效的方法,指示出是否有抗肿瘤活性。目前,初筛工作只在小鼠身上进行,用的是一种专门的白血病模型。这种方法在鉴定抗白血病和淋巴癌有活性的物质方面已经获得令人瞩目的成功。但是该法用于寻找对肺癌、直肠癌和乳腺癌这样一些常见、生长缓慢的实质性癌变具活性的物质时却不成功。现在,对每一种化合物都要用100种以上的,包括人体主要肿瘤的培养细胞株进行试验。对某种
The National Cancer Institute (NCI) is beginning to use a new tissue culture screening system. It is hoped that this system will provide a quick and efficient way to screen thousands of compounds in the facility each year, indicating whether there is antitumor activity. At present, the screening work only in mice, using a specialized leukemia model. This method has received remarkable success in identifying substances that are active against leukemia and lymphoma. But the law was unsuccessful when it was used to find substances that were active against some of the common, slow-growing, substantial cancers of lung, colorectal and breast cancer. Now, more than 100 cultured cell lines, including major human tumors, are tested for each compound. To some kind