论文部分内容阅读
目的探讨膀胱尿道原发性印戒细胞癌的临床和病理特征。方法经临床资料分析及光镜、免疫组化、电镜观察５例膀胱尿道原发性印戒细胞癌。结果肿瘤发生于膀胱者４例，发生于尿道者１例。临床表现以血尿为主伴有尿路刺激症状。组织学上以大片印戒样癌细胞、腺管样结构及粘液地形成为特征。免疫组织化学标记示癌细胞ＣＥＡ和ＥＭＡ阳性。电镜下见瘤细胞胞浆内有大量圆形粘液颗粒，中等电子密度，粘液多糖物质呈颗粒状。结论提示膀胱尿道印戒细胞癌来源于移行上皮的全能干细胞。
Objective To investigate the clinical and pathological features of primary signet ring cell carcinoma of the bladder and urethra. Methods Five cases of primary signet ring cell carcinoma of bladder and urethra were observed by clinical data, light microscope, immunohistochemistry and electron microscope. Results of the tumor occurred in 4 cases of bladder, occurred in the urethra in 1 case. Clinical manifestations of hematuria accompanied by urinary tract irritation. Histologically, large numbers of signet-ring-like cancer cells, duct-like structures, and mucus formation were characterized. Immunohistochemistry showed that the cancer cells were positive for CEA and EMA. Electron microscope, see tumor cells within the cytoplasm with a large number of circular mucus particles, medium electron density, mucus polysaccharide material was granular. Conclusions prompted urinary bladder signet ring cell carcinoma derived from transitional epithelial pluripotent stem cells.