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目的了解我市手足口病的病原学分型及流行病学特征，分析各病原学分型与临床特点的联系。方法对我市2011~2014年实验室确诊的161例手足口病例的病原学分型进行分析，比较各病原学分型的临床特点有无差异。结果161例手足口病实验室确诊病例中EV71分型55例，占34.16%，CoxA16分型54例，占33.54%，其他肠道病毒52例，占32.30%。2011~2014年病原学分型逐年有所变化，其中EV71所占比重有下降趋势。48例重症患者中27例为EV71阳性，13例为CoxA16阳性，8例为其他肠道病毒。结论我市手足口病各年流行的肠道病毒不同，各型肠道病毒引起的手足口病临床表现有所不同，重症病例大部分由EV71引起。早期诊断，对有重症倾向的病例早期干预，可以降低危重患者的病死率。“,”Objective To understand the pathogen types and epidemiology characters of hand,foot and mouth disease (HFMD)within Guanghan city;to analyse the relationship between dif erent pathogen types and clinical peculiarities.Methods To analyse the pathogen types of 161 hand,foot and mouth disease(HFMD)cases which happened in Guanghan city from 2011-2014;to compare the dif erences among dif erent pathogen types and clinical peculiarities.Results Among 161 hand,foot and mouth(HFMD)cases,the pathogen types and ratio numbers were:55 cases were caused by enterovirus 71(EV-71),34.16 percent;54 cases were caused by coxsackievirus A16 (Cox A16),33.54 percent;the rest 52 cases were caused by other enterovirus and the ratio was 32.30 percent.From 2011 to 2014,the pathogen types changed gradual y,the incidence rate of enterovirus 71(EV-71)showed the tendency of decrease.For the most severe 48 patients,there were 27 cases with enterovirus 71(EV-71)positive;13 cases with coxsackievirus A16(Cox A16)positive;8 cases with other enterovirus infectionConclusion There were dif erent types of enterovirus led to hand,foot and mouth disease(HFMD)in Guanghan city in dif erent years;which induced dif erent clinical symptoms.Most severe cases were caused by enterovirus 71(EV-71).Early diagnosis,early intervention are suggested to reduce death ratio of severe patients.