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维生素D是具有广泛生理作用的类固醇衍生物，它在人体内的作用是通过维生素 D 受体（VDR）介导的。而它的作用是通过维生素 D 受体（VDR）介导的。体内大多数组织和细胞都有VDR。随着科技基因技术的发展，发现其基因上存在多个多态性位点，且其各个位点的含量与许多疾病发生有关，在儿童时期参与佝偻病的发生，随着年龄的增长，又介导人体骨质疏松发生。该文主要介绍VDR的结构、分布、基因多态性的遗传易患性及与骨密度的相关性，为临床早期诊断以及治疗佝偻病和骨质疏松提供合适的理论依据。“,”Vitamin D is a steroid derivatives with a broad range of physiological functions .It mainly mediates cell function of vitamin D in the body,which is through vitamin D receptor(VDR).There are VDRs in most tissues and cells in the body .With the development of science and gene technology ,it has been found that there are multiple SNPs in VDR gene ,and the content of each SNP is associated with many diseases ,for instance,some SNPs participate in the occurrence of rickets during childhood,and some SNPs mediate the incidence of osteoporosis during adulthood.Here is to make a review of the VDR system structure,distribution and genetic susceptibility of VDR gene polymorphismand its correlation with bone mineral density ,so as to provide theoretical basis for early diagnosis and treatment for rickets and osteoporosis .