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长期以来脂源性学说被认为是动脉粥样硬化（ As）形成的主要学说，以他汀类药物为代表的调脂治疗，在防止As性疾病方面取得了巨大进展，可有效降低冠状动脉粥样硬化性心脏病的发病率及病死率。但是，他汀的疗效有限，不良反应多，争议不断。并且不断有研究发现氧化应激在 As的发生、发展过程中起着十分重要的作用，抗氧化药物普罗布考可稳定、延缓甚至消退动脉粥样斑块，保护血管内皮的功能，具有良好的抗As效果，能够预防以及治疗心血管疾病，最终减少心血管终末事件的发生。“,”Fat-derived doctrine has been considered the main theory of the formation of atherosclerosis (As) for a long time.With statin therapy represented,the lipid-lowering therapy has made tremendous pro-gress in preventing atherosclerotic disease.Statin can effectively reduce the morbidity and mortality of coro-nary atherosclerotic heart disease.However,its efficacy is limited with side effects and continuous controver-sies.And there have been studies finding that oxidative stress plays a very important role in the process of As.Probucol,as an antioxidant drugs,can stabilize,slow or even regress atherosclerotic plaque,which can protect endothelial function,with good anti-atherosclerotic effect.The prevention and treatment of cardiovas-cular disease can ultimately reduce the incidence of cardiovascular terminal events .