论文部分内容阅读
dl-四氢巴马汀(THP)能使大鼠伏核神经元的自发放电明显下降。本文观察脑室注射(icv)去甲肾上腺素(NA)、5-羟色胺(5-HT)和多巴胺(DA)对此抑制效应的影响。实验表明,在THP给药后30 min使伏核单位放电的抑制达峰值时icv NA(10μg/μl)能使伏核单位放电很快恢复,1 h后达给THP前水平。在给THP后30 min时,icv 5-HT(10 μg/μ1)对伏核单位放电的抑制并无影响。但在给THP后15 min伏核单位放电下降50%时,相同剂量5～HT则可使伏核单位放电的抑制作用逆转,1 h后和给THP前相似。给THP后30 min时icv DA(10 μg/μl),伏核单位的放电仍继续抑制。结果表明NA,5-HT能不同程度地对抗THP引起的伏核神经元的放电抑制效应,而DA对此抑制效应似乎并无影响。
dl-tetrahydropalmatine (THP) can significantly reduce the spontaneous discharge of rat nucleus accumbens. This study was designed to observe the effect of intracerebroventricular (icv) norepinephrine (NA), serotonin (5-HT) and dopamine (DA) on this inhibitory effect. Experiments showed that icv NA (10μg / μl) could inhibit the discharge of nucleus accumbens quickly after 30 min of THP administration, and reach the pre-THP level 1 h later. At 30 min after THP administration, icv 5-HT (10 μg / μ1) had no effect on the inhibition of nuclear discharge. However, when the discharge of nucleus accumbens decreased by 50% at 15 min after THP administration, the same dose of 5 ~ HT reversed the inhibitory effect of discharge of nucleus accumbens. Similar to that before THP was observed after 1 h. At 30 min after THP, icv DA (10 μg / μl) and the discharge of nucleus accumbens continued to be inhibited. The results showed that 5-HT could antagonize the inhibitory effect of THP-induced neuronal firing to varying degrees, while DA did not appear to have any effect on this inhibitory effect.