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在多剂给药中,尽快获得并始终维持血药稳态水平是临床用药的一个重要问题。对此,著名药物动力学家E krvger-Thiemer提出了第一剂给负荷剂量D,以后各剂给维持剂量D的方案。当前临床上普遍采用这种给药方法。此法的依据是:如果按E krvger-Thiemer提出的负荷剂量公式给药,体内血药浓度在第一个给药周期内,就能升到有效浓度(最低坪水平)以上;并在给药周期末恰好等于最低坪水平。因此认为,以后各剂,只要
In multi-dose administration, obtaining and maintaining the steady state blood level as soon as possible is an important issue in clinical use. In response, the famous pharmacokinetic Ekrvger-Thiemer proposed the first dose to the load D, after the dose to maintain the dose of D program. The current clinical practice of this method of administration. This method is based on the fact that if the drug load formula given by Erkräger-Thiemer is used, the in vivo plasma concentration rises above the effective concentration (lowest plateau level) during the first dosing cycle; The end of the cycle is exactly equal to the lowest ping level. Therefore, after the various agents, as long as