论文部分内容阅读
Objective:To identify the differences among preinvasive lesions,minimally invasive adenocarcinomas (MIAs) and invasive pulmonary adenocarcinomas (IPAs) based on radiomic feature analysis with computed tomography Methods:A total of 109 patients with ground-glass opacity lesions (GGOs) in the lungs determined by CT examinations were enrolled,all of whom had received a pathologic diagnosis.After the manual delineation and segmentation of the GCOs as regions of interest (ROIs),the patients were subdivided into three groups based on pathologic analyses:the preinvasive lesions (including atypical adenomatous hyperplasia and adenocarcinoma in situ) subgroup,the MIA subgroup and the IPA subgroup.Next,we obtained the texture features of the GGOs.The data analysis was aimed at finding both the differences between each pair of the groups and predictors to distinguish any two pathologic subtypes using logistic regression.Finally,a receiver operating characteristic (ROC) curve was applied to accurately evaluate the performances of the regression models.Results:We found that the voxel count feature (P＜0.001) could be used as a predictor for distinguishing IPAs from preinvasive lesions.However,the surface area feature (P=0.040) and the extruded surface area feature (P=0.013) could be predictors of IPAs compared with MIAs.In addition,the correlation feature (P=0.046) could distinguish preinvasive lesions from MIAs better.Conclusions:Preinvasive lesions,MIAs and IPAs can be discriminated based on texture features within CT images,although the three diseases could all appear as GGOs on CT images.The diagnoses of these three diseases are very important for clinical surgery.