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Objective:The standard treatment for patients with Locally advanced gastric cancer has relied on perioperative radio-chemotherapy or chemotherapy and surgery.The aim of this study was to investigate the wealth of radiomics for pre-treatment computed tomography (CT) in the prediction of the pathological response of locally advanced gastric cancer with preoperative chemotherapy.Methods:Thirty consecutive padents with CT-staged Ⅱ/Ⅲ gastric cancer receiving neoadjuvant chemotherapy were enrolled in this study between December 2014 and March 2017.All patients underwent upper abdominal CT during the unenhanced,late arterial phase (AP) and portal venous phase (PP) before the administration of neoadjuvant chemotherapy.In total,19,985 radiomics features were extracted in the AP and PP for each patient.Four methods were adopted during feature selection and eight methods were used in the process of building the classifier model.Thirty-two combinations of feature selection and classification methods were examined.Receiver operating characteristic (ROC) curves were used to evaluate the capability of each combination of feature selection and classification method to predict a non-good response (non-GR) based on tumor regression grade (TRG).Results:The mean area under the curve (AUC) ranged from 0.194 to 0.621 in the AP,and from 0.455 to 0.722 in the PP,according to different combinations of feature selection and the classification methods.There was only one cross-combination machine-leing method indicating a relatively higher AUC (＞0.600) in the AP,while 12 cross-combination machine-leing methods presented relatively higher AUCs (all ＞0.600) in the PP.The feature selection method adopted by a filter based on linear discriminant analysis + classifier of random forest achieved a significandy prognostic performance in the PP (AUC,0.722±0.108;accuracy,0.793;sensitivity,0.636;specificity,0.889;Z=2.039;P=0.041).Conclusions:It is possible to predict non-GR after neoadjuvant chemotherapy in locally advanced gastric cancers based on the radiomics of CT.