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目的:建立标准化的上下气道炎症评估方法。方法:通过对上下气道炎性疾病的相关课题的研究,摸索出上下气道炎症评估(鼻肺部NO、气道高反应性及细胞学)的方法及相应正常值。结果:鼻部NO正常值范围为400~900ppb,肺部为5~25ppb;鼻激发后鼻阻力较基础值增加≥100%,支气管激发FEV1较基础值下降≥20%,判定为阳性;鼻灌洗Eos≥2.00/HP,诱导痰Eos≥2.5%为阳性。结论:上下气道炎症评估方法的标准化为上下气道的后续研究提供了相关的方法学及研究基础。
Objective: To establish a standardized method for assessment of upper and lower airway inflammation. Methods: Through the research on the related topics of upper and lower airway inflammatory diseases, the method of upper and lower airway inflammation evaluation (nasal lung NO, airway hyperresponsiveness and cytology) and corresponding normal values were explored. Results: The nasal NO ranged from 400 to 900 ppb in normal range and 5 to 25 ppb in lung. Nasal resistance increased more than 100% after nasal challenge, and FEV1 decreased more than 20% in basal bronchial provocation. Wash Eos ≥2.00 / HP, induced sputum Eos ≥ 2.5% were positive. CONCLUSIONS: The standardization of upper and lower airway inflammation assessment methods provides the relevant methodological and research basis for subsequent studies of the upper and lower airway.