支气管哮喘和慢性阻塞性肺疾病患者血清Eotaxin检测分析

• 作 者: 谢永平 黎国梅 李静宇 黄华成 唐雪玲 叶伟南 伦秀红
• 机 构: 肇庆市结核病防治所,郁南县慢性病防治站,
• 出 处: 中国热带医学
• 发表日期: 2012年01期
• 关键词: 支气管哮喘 慢性阻塞性肺疾病 嗜酸性粒细胞趋化因子 检测

目的探讨嗜酸性粒细胞趋化因子(Eotaxin)在支气管哮喘(简称哮喘)和慢性阻塞性肺疾病(COPD)患者血清中的水平变化。方法用双抗体夹心抗体酶联免疫吸附法检测56例哮喘、27例急性加重期COPD患者以及20例正常人血清Eotaxin的水平。结果哮喘急性发作期组血清Eotaxin水平显著高于慢性持续期组(P<0.05)以及其余三组(P<0.01),哮喘慢性持续期组显著高于COPD组(P<0.05)及健康对照组(P<0.01),但与缓解期组比较差异无统计学意义(P>0.05);哮喘缓解期组、COPD组与健康对照组两两比较差异无统计学意义(P>0.05)。结论 Eotaxin可能通过对过敏性炎性细胞的激活和从血中向支气管粘膜浸润过程的调控,与支气管哮喘的病理生理过程有关,尤其与支气管哮喘急性发作和疾病严重程度密切相关,哮喘组血清Eotaxin水平与COPD比较具有一定的鉴别诊断意义。

Objective To investigate the changes of serum levels of eotaxin in patients with bronchial asthma (asthma) and chronic obstructive pulmonary disease (COPD). Methods The levels of serum Eotaxin in 56 asthmatic patients, 27 acute exacerbation COPD patients and 20 normal controls were detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results Serum levels of Eotaxin in acute exacerbation of asthma group were significantly higher than those in chronic persistent phase group (P <0.05) and the other three groups (P <0.01), chronic asthma group was significantly higher than that in COPD group (P <0.05) and healthy control group (P <0.01), but there was no significant difference between the remission group and the remission group (P> 0.05). There was no significant difference between the remission group and the COPD group and the healthy control group (P> 0.05). Conclusion Eotaxin may be related to the pathophysiological process of bronchial asthma, especially the acute exacerbation of bronchial asthma and the severity of the disease through the activation of allergic inflammatory cells and the regulation of infiltration into the bronchial mucosa from the blood. Eotaxin The level of COPD compared with a certain differential diagnosis.