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目的探讨老年急性冠脉综合征(ACS)患者血外周血T淋巴细胞亚群水平变化与发病关系。方法采用SAP法分别测定28例老年ACS患者、34例老年对照组(NC)的外周血T淋巴细胞亚群水平。结果ACS组CD 3+、CD 4+、CD 4+/CD 8+比值低于NC组(P<0.001),而CD 8+则高于NC组(P<0.001)。结论老年ACS患者存在细胞免疫功能紊乱,可能对老年ACS的形成和发展产生了影响。T淋巴细胞亚群比值变化可作为老年ACS严重程度的监测指标,免疫干预可能成为防治老年ACS的新途径。
Objective To investigate the relationship between the change of peripheral blood T lymphocyte subsets and the pathogenesis of senile acute coronary syndrome (ACS). Methods The levels of peripheral blood T lymphocyte subsets in 28 elderly ACS patients and 34 elderly controls (NC) were determined by SAP method. Results The ratio of CD 3 +, CD 4 +, CD 4 + / CD 8+ in ACS group was lower than that in NC group (P <0.001), while CD 8+ was higher than that in NC group (P <0.001). Conclusion The elderly patients with ACS have cellular immune dysfunction, which may have an impact on the formation and development of elderly ACS. T lymphocyte subsets ratio changes can be used as a monitoring indicator of the severity of ACS in the elderly, immune intervention may be a new way to prevent and treat elderly ACS.