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为了提高全反式维甲酸（ATRA）治疗急性早幼粒细胞白血病（APL）诱发高白细胞症的疗效，对21例APL在ATRA治疗中出现的高白细胞症进行观察，并用羟基脲或三尖杉酯碱治疗。结果显示：对白细胞上升较迟峰值较低的普通组高白细胞症患者用羟基脲治疗有效，而对白细胞上并迅速且峰值较高的严重组高白细胞症患者用三尖杉酯碱治疗有较好的疗效。
In order to improve the efficacy of all-trans retinoic acid (ATRA) in the treatment of acute promyelocytic leukemia (APL)-induced hyperleukocytosis, 21 cases of APL with high leucocyte counts observed in ATRA treatment were treated with hydroxyurea or cephalosporin Ester alkali treatment. The results showed that hydroxyurea treatment was effective for patients with common group of high leukemia who had a later peak of white blood cell rise, but it was more effective for patients with high leukocyte disease who had rapid and high peak leukocytes and treated with harringtonine. Good effect.