【摘 要】
：
A quinine-derived thiourea-catalyzed inter-/intramolecular Michael cycloaddition of chromone-oxindole/benzofuranone synthons with 3-substituted methylenebenzofu
【机 构】
：
Guizhou Engineering Center for Innovative Traditional Chinese Medicine and Ethnic Medicine, Guizhou
论文部分内容阅读
A quinine-derived thiourea-catalyzed inter-/intramolecular Michael cycloaddition of chromone-oxindole/benzofuranone synthons with 3-substituted methylenebenzofuranones has been established, which constructed enantiomerically pure bispiro[benzofuran-oxindole/benzofuran-chromanone]s bearing five consecutive stereocenters including two spiro quatary carton centers in good yields (up to 93％) with high diastereoselectivities (up to>20:1 dr) and good enantioselectivities (up to>99％ee). Moreover, this is the first example of bifunctional chromone-benzofuranone synthon directed organocatalytic tandem reaction, and also the first example of the bispiro[benzofuran-oxindole] and bispirobenzofuranone, potentially useful in medicinal chemistry.
其他文献
β-Elemene is a volatile oil used for the treatment of cancer, but poor solubility, low bioavailability, and variousadversereactionslimititsapplication.Forameli
A new star-shaped molecule StOF-Br3 containing oligofluorenes and halogen atoms (Bromine) has been synthesized and studied by Scanning Tunneling Microscopy (STM
Polylactic acid (PLA) is one of the most suitable candidates for environmental pollution treatment because of its biodegradability which will not cause secondar
A heteropore covalent organic framework (COF) integrating tetraphenylethene skeleton and catechol segment is designed and synthesized. It exhibits extremely hig
A new silver mediated aminophosphinoylation of propargyl alcohols with aromatic amines and H-phosphine oxides for the construction of α-aminophosphine oxides h
A selective ring-opening [3+2] cyclization reaction of benzo[d]isoxazoles with 2-bromo-propanamides hasbeendeveloped.Theazaoxyallylcationintermediatesareemploye
A seven-step total synthesis of α-cyclopiazonic acid is reported from a commercially available 4-bromoindole. Salient feature of the work is the rapid formatio
An efficient water-based bismuth-mediated addition reaction of carbonyl compound with cyclic allylic halide was developed. The reactions proceeded smoothly in a
Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new an
In this study, we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibitors. MTT assays indicated that most of th