Ring opening [3+2] cyclization of azaoxyallyl cations with benzo[d]-isoxazoles:Efficient access to 2

• 作 者: Yicheng He Chao Pi Yangjie Wu Xiuling Cui
• 机 构: Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laborat
• 出 处: 中国化学快报（英文版）
• 发表日期: 2020年2期
• 关键词: Azaoxyallylic cations Ring-opening [3+ 2] Cycloaddition 2-Hydroxyaryl-oxazolines

A selective ring-opening [3+2] cyclization reaction of benzo[d]isoxazoles with 2-bromo-propanamides hasbeendeveloped.TheazaoxyallylcationintermediatesareemployedasC ～O3-atomsynthontobuild oxa-heterocycles via the selectivity of suitable cyclization partners. This transformation provides rapid access to highly functionalized 2-hydroxyaryl-oxazolines under mild conditions and excellent regioselectivity.