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作者对184例非何杰金氏淋巴瘤中经最后确诊的17例成人原发性纵膈淋巴瘤进行研究。病理类型:17例原发性纵隔淋巴瘤均属弥漫型。按照 Rappaport 病理分型,其中11例为弥漫型低分化淋巴细胞性淋巴瘤;6例为弥漫型组织细胞性淋巴瘤。前者11例中9例为原始淋巴细胞性淋巴瘤,若按Barcos 等描述,这些肿瘤由具形态卷曲特征的恶性淋巴细胞所组成;余下2例则为小核裂滤泡中心细胞。免疫学表面标记研究:直接从纵隔肿瘤处获取组织作免疫学检查甚为困难,有8例从其他受累部位取得标本研究。对5例原淋巴细胞性/卷曲性淋巴瘤中的4例,发现大多数肿瘤细胞(>50%)能与绵羊红细胞形成自然玫瑰花结,另1例形成玫瑰花结的百分率较低,该例标本混有恶性细胞及正常淋巴细胞,此5例瘤细胞表面均未发现有意义的免疫球蛋白。2例弥漫型组织细胞性淋巴瘤免疫学标记结果:1例用特
The authors studied 184 newly diagnosed adult primary mediastinal lymphoma in 184 non-Hodgkin’s lymphoma cases. Pathological type: 17 cases of primary mediastinal lymphoma are diffuse. According to the pathological classification of Rappaport, 11 cases were diffusely differentiated lymphocytic lymphoma; 6 cases were diffuse histiocytic lymphoma. In the former 11 cases, 9 cases were primitive lymphocytic lymphoma. If described by Barcos et al, these tumors consisted of malignant lymphocytes with morphological curly features; the remaining 2 cases were small cleavage center cells. Immunological Surface Marker Research: It is very difficult to obtain tissue directly from the mediastinal tumor for immunological examination, and 8 specimens from other affected sites were obtained. Of the 5 cases of prolymphocytic / cirrhotic lymphoma, most of the tumor cells (> 50%) were found to form natural rosette with sheep erythrocytes, while the other cases had a lower percentage of rosette formation, Cases of specimens mixed with malignant cells and normal lymphocytes, the five cases of tumor cells found no significant immunoglobulin surface. 2 cases of diffuse histiocytic lymphoma immunological markers results: 1 case with special