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硫杂脯氨酸(Timonacic,又名Norgamen,Thioproline,Hepalidine,Heparegene,ATC,Detoxepa,Tiazolidin,Thiazic acid),化学名为L-噻唑烷-4-羧酸,是一个新型抗肿瘤药物。它的发现有人认为是1948年发现甲氨蝶呤以来肿瘤化学治疗一个较重大的进展,受到了广泛重视。一、逆向转化及其筛选方法 1971年,Puck和Pastan两研究组分别发现二丁酰环腺苷酸能使组织培养的肿瘤细胞逆向转化,使形态接近于正常细胞,质膜的结构与功能恢复原状,特别是已经失去的“接
Thiaproline (Timonacic, also known as Norgamen, Thioproline, Hepalidine, Heparegene, ATC, Detoxepa, Tiazolidin, Thiazic acid), the chemical name is L- thiazolidine-4-carboxylic acid, is a new anti-tumor drug. Its discovery was considered one of the more significant advances in the chemotherapeutic treatment of tumors since methotrexate in 1948 and received widespread attention. First, the reverse transformation and screening methods In 1971, Puck and Pastan two groups were found dibutyryl cyclic adenosine can reverse the tissue culture of tumor cells so that the morphology close to normal cells, the structure and function of the plasma membrane restored to its original state, In particular, have been lost, "then