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目的:探讨C反应蛋白(CRP)检测在足月胎膜早破(PROM)孕妇中的临床意义。方法:选取足月胎膜早破(PROM)孕妇50例为实验组,并根据破膜时间将足月破膜孕妇分为3个亚组;并选取同期住院的正常孕妇30例为对照,采用高敏CRP试剂盒,测定不同组别孕妇中CRP水平。结果:入院时,胎膜早破各亚组中CRP水平明显高于对照组,具有显著统计学意义(P<0.05);同时随着破膜时间的增加,各亚组中的CRP水平及WBC计数也逐渐升高,且3个亚组之间也分别存在统计学差异(P<0.05)。在应用抗生素3d后,CRP出现显著下降,与正常组相比未见明显差异(P>0.05);WBC计数在应用抗生素后的3d时间出现下降,但与入院前相比未见明显统计学差异。结论:CRP检测在判断孕妇胎膜早破、指导临床用药方面具有较高的临床价值,可作为常规检查项目。
Objective: To investigate the clinical significance of C-reactive protein (CRP) in pregnant women with term premature rupture of membranes (PROM). Methods: Fifty pregnant women with full-term premature rupture of membranes (PROM) were selected as the experimental group. According to the time of rupture, the full-term rupture of membranes was divided into three subgroups. 30 normal pregnant women were enrolled in this study. High-sensitivity CRP kit, determination of different groups of pregnant women CRP levels. Results: At the time of admission, CRP levels in each subgroup of premature rupture of membranes were significantly higher than those in control group (P <0.05). Meanwhile, with the increase of rupture time, CRP levels in all subgroups and WBC The counts also increased gradually, and there were also statistical differences among the three subgroups (P <0.05). After 3 days of antibiotic treatment, the CRP decreased significantly compared with that of the normal group (P> 0.05). The WBC count decreased 3 days after the antibiotic treatment but no significant difference compared with pre-admission . Conclusion: The CRP test has high clinical value in judging the premature rupture of membranes in pregnant women and guiding the clinical medication, which can be used as a routine examination item.