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2006年Yamanaka等首次报道通过特定的因子把小鼠的成纤维细胞重新编程为多能干细胞后,诱导性多能干细胞(induced pluripotent stem,iPS)的研究获得了惊人的发展。多个研究组报道从小鼠的体细胞重新诱导出与ES细胞特性几乎同样的iPS细胞[1,2];iPS的产生可以不需要药物的选择;很
Yamanaka et al. First reported the remarkable development of the study of induced pluripotent stem (iPS) after reprogramming mouse fibroblasts into pluripotent stem cells by specific factors in 2006. Several groups have reported that somatic cells in mice reintroduce iPS cells that have almost the same characteristics as ES cells [1, 2]; iPS production may not require drug selection;