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糖尿病肾病(DN)是糖尿病严重的微血管并发症之一,目前该机制并不十分清楚,但是得到普遍认可的是,DN与葡萄糖转运子-1、血管紧张素Ⅱ、转化生长因子,内皮素A等系统有关,糖尿病肾病的病理改变包括在肾小球周围出现嗜酸性结节,肾小球基膜增厚以及肾小球增大,这些病理性的改变与高糖血症导致机体异常代谢以及血流动力学的改变和高血压与终末期糖尿病肾病的密切关系。本文主要论述降糖药以及降压药对糖尿病肾病的疗效以及目前一些针对DN的新型药物的介绍。
Diabetic nephropathy (DN) is one of the most important microvascular complications of diabetes. At present, the mechanism is not well understood. However, it is generally accepted that DN is associated with glucose transporter-1, angiotensin II, transforming growth factor, endothelin A And other systems, pathological changes in diabetic nephropathy include eosinophilic nodules around the glomerular, glomerular basement membrane thickening and glomerular enlargement, these pathological changes and hyperglycemia lead to abnormal metabolism of the body and Hemodynamic changes and the close relationship between hypertension and end-stage diabetic nephropathy. This article focuses on hypoglycemic agents and antihypertensive drugs in the treatment of diabetic nephropathy and the current introduction of some new drugs for DN.