Synthesis, Crystal Structure and Biological Activity of 6-Arylmethyl-7H-thiazolo[3,2-b]-1,2,4-triazi

• 作 者: GAO Di TAN Xiao-Yu AN Tian-Tia
• 机 构: KeyLaboratoryofStructure-basedDrugDesign&,Discovery,SchoolofPharmacy
• 出 处: 结构化学
• 发表日期: 2019年10期
• 关键词: thiazolo[3 2 -b]-1 2 4-triazine DERIVATIVES SYNTHESIS CRYSTAL structure antitumo
• 基金项目: This work was supported by the National Natural Science Foundation of China(No.21342006),the Program for Innovative Research Team of the Ministry of Education of China(No.IRT14R36)

In order to explore the novel anti-tumor agents,ten 6-arylmethyl-3-aryl-777-thiazolo[3,2-b],2,4-triazin-7-ones were designed and synthesized,and the structures were characterized by ^1H-NMR,MS,IR and X-ray single-crystal diffraction analysis.The biologica