Synthesis,Crystal Structure,DFT Studies and Antifungal Activity of 5-（4-Cyclopropyl-5-（（3-fluorobenz

• 作 者: ZHAI Zhi-Wen SHI Yan-Xia YANG
• 机 构: CollegeofChemicalEngineering,InstituteofVegetablesandFlowers,BiologyInstituteofShandongAcademyofScie
• 出 处: 结构化学
• 发表日期: 2016年1期
• 关键词: 抗真菌活性 密度泛函理论 晶体结构 磺酰基 噻二唑 合成 苄基 结构活性关系 1 2 3-thiadiazole 1 2 4-triazole synthesi
• 基金项目: funded by National Natural Science Foundation of China（No.21002090）, the National Key Technologies R＆D Program（2011BAE06B03-01）

5-(4-Cyclopropyl-5-((3-fluorobenzyl)sulfonyl)-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole was synthesized and recrystallized from Et OH. The compound was characterized by ~1H NMR,MS,elemental analysis and X-ray diffraction. The structure-active rela