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目的：探讨慢性乙型肝炎（ＣＨＢ）患者血清可溶性细胞间粘附分子１（ｓＩＣＡＭ１）水平与肝损害的关系。方法：用ＥＬＩＳＡ检测正常人、慢性无症状ＨＢｓＡｇ携带者（ＡｓＣ）和ＣＨＢ患者血清ｓＩＣＡＭ１。结果：ＣＨＢ患者血清ｓＩＣＡＭ１明显高于正常人和ＡｓＣ；ＣＨＢ患者血清ｓＩＣＡＭ１水平与其血清门冬氨酸转氨酶（ＡＳＴ）和总胆红素均呈明显正相关，与凝血酶原活动度呈明显负相关；重度ＣＨＢ患者血清ｓＩＣＡＭ１明显高于中、轻度ＣＨＢ。结论：ＣＨＢ患者血清ｓＩＣＡＭ１水平均有不同程度升高，血清ｓＩＣＡＭ１水平可作为反映ＣＨＢ患者肝损害程度的指标之一。
Objective: To investigate the relationship between serum soluble intercellular adhesion molecule-1 (sICAM-1) and liver damage in patients with chronic hepatitis B (CHB). Methods: Serum sICAM1 was detected in normal subjects, chronic asymptomatic HBsAg carriers (AsC) and CHB patients by ELISA. Results: The levels of serum sICAM-1 in CHB patients were significantly higher than those in normal subjects and AsC patients. Serum sICAM-1 levels in CHB patients were positively correlated with serum aspartate aminotransferase (AST) and total bilirubin, Was significantly negative correlation; severe CHB serum sICAM 1 was significantly higher than in mild CHB. Conclusion: The levels of serum sICAM-1 in CHB patients are all increased to some extent. The level of serum sICAM-1 can be used as one of the indicators reflecting the degree of liver damage in patients with CHB.