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作者研究了一些 HBsAg 阴性的慢性活动性肝炎患者,观察其血清中有无抗-HBc和由 HBV 感染所致的肝病,以证明抗-HBc是一个比 HBsAg 更为敏感的 HBV 复制指标。100例患者,男女各半,均经组织学证实为慢性活动性肝炎,按 De Groote 等的组织学分类标准,肝损害属中等活动度者为75例,重度活动度者为25例。肝活检时测定SGPT。用放射免疫法检测血清中 HBsAg,用对流电泳法检测抗-HBc,并用补体结合法测定抗-HBc 的滴度。
The authors studied some HBsAg-negative patients with chronic active hepatitis and observed their presence or absence of anti-HBc in the serum and liver disease due to HBV infection to demonstrate that anti-HBc is a more sensitive indicator of HBV replication than HBsAg. 100 patients, half male and half female, were histologically confirmed as chronic active hepatitis. According to the histological classification criteria of De Groote et al, 75 were moderately active and 25 were moderately severe. SGPT was determined on liver biopsy. Serum HBsAg was detected by radioimmunoassay, anti-HBc by convective electrophoresis, and anti-HBc titer by complement fixation assay.