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目的:研究盐酸布替萘芬乳膏对离体豚鼠皮的透皮吸收情况,并对自制乳膏与国内外已上市产品的离体透皮渗透量进行比较。方法:采用透皮吸收仪,皮片涂药后不同时间采样,用高效液相色谱法测定样品中盐酸布替萘芬的浓度。结果:在50%乙醇生理盐水释放液中,国外产品、国内产品和自制产品36 h透皮渗透量分别只有0.061 89,4.661,和0.289 7μg.cm-2,盐酸布替萘芬乳膏透皮渗透量很低,三者无显著性差异。结论:自制盐酸布替萘芬乳膏的豚鼠离体透皮吸收程度与国外同类品种相当。盐酸布替萘芬乳膏主成分大部分滞留在皮肤,只有极少数透过皮肤屏障,有利于其发挥局部治疗作用。
OBJECTIVE: To study the percutaneous absorption of budesonide hydrochloride cream on isolated guinea pig hides and to compare the in vitro transdermal penetration of self-made cream with that of domestic and foreign products. Methods: Percutaneous absorption instrument was used to sample skin samples at different times after application. The concentration of butenafine hydrochloride in the samples was determined by high performance liquid chromatography. Results: The permeation amount of 36 h transdermal permeation of foreign products, domestic products and homemade products in 50% ethanol saline solution were only 0.061 89, 4.661 and 0.289 7 μg.cm-2, respectively. The budesonide hydrochloride cream transdermal Penetration is very low, the three no significant difference. CONCLUSION: The transdermal absorption in vitro of guinea pigs with self-made butenafine hydrochloride cream is comparable to that of foreign counterparts. Most of the main components of butenafine hydrochloride cream remain in the skin, only a very small number through the skin barrier, is conducive to its local therapeutic effect.