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本文阐述了一条立体专一性合成3-羟基-4-取代-2-吖丁啶酮的路线,并以乙酰氧基乙酰氯和亚胺为原料,在三乙胺存在下,经环合加成得到标题化合物,除5a、5b外,其余均属首次合成,研究了亚胺上不同取代基对环加成反应的立体化学和氧化脱N-芳基反应的影响.
This article describes a stereospecific synthesis of 3-hydroxy-4-substituted-2-azetidinone route, and acetoxyacetyl chloride and imine as raw materials, in the presence of triethylamine by cyclization plus To obtain the title compound, in addition to 5a, 5b, the rest are the first synthesis, the imine different substituents on the cycloaddition reaction stereochemistry and oxidative de-N-aryl reaction.