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25例Ⅱ型糖尿病病人用吡磺环已脲治疗,每天剂量5～30mg,持续追踪观察6个月,总有效率为88％。治疗前后吡磺环己脲-葡萄糖介导胰岛素分泌面积无改变,但葡萄糖介导胰岛素分泌面积、胰岛素敏感性和葡萄糖利用常数(K_I)明显升高。提示该药的降糖作用除刺激胰岛B细胞分泌胰岛素、改善葡萄糖介导胰岛素分泌外,还改善机体对胰岛素的敏感性。
Twenty-five patients with type II diabetes were treated with pyriphosphamide and carbamide. The daily dose was 5-30 mg. The patients were followed up for 6 months and the total effective rate was 88%. Before and after treatment with glipizide - glucose-induced insulin secretion area did not change, but glucose-mediated insulin secretion area, insulin sensitivity and glucose utilization constant (K_I) was significantly increased. Tip of the drug hypoglycemic effect in addition to stimulate islet B cells to secrete insulin to improve glucose-mediated insulin secretion, but also improve the body’s sensitivity to insulin.