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肾功衰竭继发甲状旁腺机能亢进的治疗还有待研究。维生素D或其活性代谢产物可增加血清钙浓度,促进肠道钙吸收。近来,人们已公认1,25-(OH)_2VD_3(骨化三醇)对甲状旁腺功能有重要作用。甲状旁腺组织含有骨化三醇受体,骨化三醇可抑制甲状旁腺激素(PTH)基因表达及甲状旁腺细胞增殖。作者研究21例晚期肾衰患者,年龄3～21岁,其中血液透析(HD)者7例,不卧床持续腹膜透析(CAPD)者14例。骨化三醇治疗剂量为每天口服0.25～1μg。PTH浓度(正常1～6 pmol/L)轻度增高至50 pmol/L
The treatment of secondary hyperparathyroidism due to renal failure remains to be studied. Vitamin D or its active metabolite can increase serum calcium concentration, promote intestinal calcium absorption. Recently, it has been recognized that 1,25- (OH) _2VD_3 (calcitriol) has an important role in parathyroid function. Parathyroid tissue contains calcitriol receptor, calcitriol can inhibit parathyroid hormone (PTH) gene expression and parathyroid cell proliferation. The authors studied 21 patients with advanced renal failure, aged 3 to 21 years, of whom hemodialysis (HD) in 7 cases, ambulatory continuous peritoneal dialysis (CAPD) in 14 cases. Calcitriol treatment dose of 0.25 ~ 1μg orally per day. PTH concentration (normal 1 ~ 6 pmol / L) increased slightly to 50 pmol / L