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铁代谢异常可能通过多种途径参与肺动脉高压的发生发展。目前研究发现铁缺乏、铁代谢紊乱普遍存在于特发性肺动脉高压和遗传性肺动脉高压人群中。铁代谢异常既可能是肺动脉高压发生的原因，也可能成为肺动脉高压治疗的靶点。“,”Iron may involved in the development of pulmonary arterial hypertension from several different mechanisms.Evidence indi-cates that iron deficiency is prevalent in idiopathic and heritable forms of pulmonary arterial hypertension.Iron homeostasis disorder may be the reason of pulmonary arterial hypertension,and on the other hand,iron supplementation may be effective for pulmonary arterial hyperten-sion.