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检测了３６例原发性肾病综合征患儿外周血糖皮质激素受体（ＧＣＲ）、血浆促肾上腺皮质激素（ＡＣＴＨ）及皮质醇水平、结果显示：肾病综合征患儿血浆ＡＣＴＨ及皮质醇水平低于正常对照组（Ｐ＜０．０１），单纯性肾病综合征组ＧＣＲ水平高于正常对照组。应用糖皮质激素（ＧＣ）２４小时后ＧＣＲ水平下降，以单纯性肾病组下降明显。结果表明，肾病综合征患儿外周血ＧＣＲ水平与ＧＣ疗效关系密切，ＧＣＲ水平高者对ＧＣ疗效好，提示通过检测ＧＣＲ数量及其变化可预测ＧＣ对肾病综合征患儿的疗效。
Peripheral blood glucocorticoid receptor (GCR), plasma adrenocorticotropic hormone (ACTH) and cortisol levels were measured in 36 children with primary nephrotic syndrome. The results showed that plasma ACTH and cortisol levels were low in children with nephrotic syndrome In the normal control group (P <0.01), the level of GCR in simple nephrotic syndrome group was higher than that in the normal control group. Glucocorticoid (GC) 24 hours after the GCR level decreased to simple nephropathy decreased significantly. The results showed that the peripheral blood GCR levels in children with nephrotic syndrome are closely related to the efficacy of GC. High GCR patients have a good curative effect on GC, suggesting that GC can predict the effect of GC on children with nephrotic syndrome by detecting the number of GCRs and their changes.