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目的研究药物洗脱支架(drug-eluting stent,DES)突起高度对药物释放动力学和血流动力学的影响,为DES的优化设计提供依据。方法采用计算流体动力学(computational fluid dynamics,CFD)方法,对血流动力学和药物释放动力学进行耦合分析,考虑3种不同突起高度支架,研究血管壁组织中药物含量和壁面切应力的分布。结果支架突起高度的增加将有利于药物的沉积,但将增加低切应力区长度。比较而言,血管壁中药物含量随着突起高度增加的幅度远小于低切应力区长度的增加。结论综合考虑药物浓度和壁面切应力两种因素,建议适当降低支架的突起高度,以便更有效地降低再狭窄产生的几率。
Objective To study the effects of height of drug-eluting stent (DES) on drug release kinetics and hemodynamics, and provide evidence for the optimal design of DES. Methods The computational fluid dynamics (CFD) method was used to analyze the hemodynamics and drug release kinetics. Three different height-height stents were used to study the distribution of drug content and wall shear stress in the vascular wall tissue . Results The increase of the height of scaffolds will be beneficial to the deposition of drug, but will increase the length of low shear stress zone. In comparison, the increase of the drug content in the vascular wall with the protrusion height is far less than the increase of the length of the low shear stress region. Conclusion Considering both drug concentration and wall shear stress, it is advisable to reduce the height of the stent in order to reduce the probability of restenosis more effectively.