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正常生殖功能的维持有赖于内源性GnRH对促性腺激素分泌的控制。因此长期给予GnRH或GnRH激动剂(GnRH-Ag)对某些种系的两性均可有“自相矛盾”的抗生育作用。GnRH对垂体、性腺和生殖道都有作用。已知GnRH的流产作用是由于其对卵巢的直接作用,抑制血孕酮(P)水平,但可因补充外源性P而使GnRH的流产作用逆转。作者为确定GnRH是否通过抑制卵巢甾体激素合成而起流产作用进行了下列研究。研究采用Sprague Dawley大鼠,饲养于室温24～26℃,每天光照14小时。自由摄食和水。以交配日为D_1,
Normal reproductive function depends on the maintenance of endogenous GnRH gonadotropin secretion control. Thus, long-term administration of GnRH or GnRH agonist (GnRH-Ag) may have “paradoxical” anti-fertility effects on both genders. GnRH has effects on the pituitary, gonads and genital tract. The abortion effect of GnRH is known to be due to its direct effect on the ovary and inhibition of blood progesterone (P) levels, but the abortion effect of GnRH may be reversed by the exogenous P supplementation. The authors conducted the following study to determine if GnRH abortions by inhibiting ovarian steroid hormone synthesis. Sprague Dawley rats were used and housed at room temperature 24-26 ° C for 14 hours daily. Free feeding and water. To mating day D_1,