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目的:探讨血栓通注射液对急性脑出血患者血清IL-8、IL10以及与颅内血肿水平影响及临床意义。方法:选取我院收治的急性脑出血患者80例,随机分为对照组及实验组,对照组以常规消肿治疗,实验组在对照组基础上予以血栓通注射液活血消肿治疗。比较各组患者治疗前后IL-8、IL-10、TNF-α、CRP水平、颅内血肿面积、层数和低密度影像水平以及NIHSS功能评分变化情况。结果:与治疗前比较,两组患者IL-8、IL-10、TNF-α、CRP及颅内血肿水平均降低(P<0.05);与对照组相比较,实验组患者治疗后IL-8、IL-10、TNF-α、CRP及颅内血肿水平较低(P<0.05);NIHSS功能评分较高,差异具有统计学意义(P<0.05)。结论:血栓通注射液可改善急性脑出血患者血肿周围脑组织水肿状态及炎性反应状态,降低炎性因子及坏死因子的释放,改善病灶区脑组织血液循环,可作为临床有效治疗方案。
Objective: To investigate the effect of Xueshuantong injection on serum IL-8, IL10 and intracranial hematoma in patients with acute cerebral hemorrhage and its clinical significance. Methods: A total of 80 acute cerebral hemorrhage patients admitted to our hospital were randomly divided into control group and experimental group. The control group was treated with conventional detuning treatment. The experimental group was treated with Xueshuantong injection and blood circulation swelling on the basis of the control group. The levels of IL-8, IL-10, TNF-α, CRP, intracranial hematoma area, stratum and low-density imaging and NIHSS scores before and after treatment in each group were compared. Results: Compared with those before treatment, the levels of IL-8, IL-10, TNF-α, CRP and intracranial hematoma decreased in both groups (P <0.05). Compared with the control group, , IL-10, TNF-α, CRP and intracranial hematoma were lower (P <0.05). NIHSS scores were higher, the difference was statistically significant (P <0.05). Conclusion: Xueshuantong injection can improve the brain edema and inflammatory reaction in patients with acute intracerebral hemorrhage, reduce the release of inflammatory cytokines and necrosis factor, and improve the blood circulation of brain tissue in the lesion area, which can be used as a clinically effective treatment.