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范科尼贫血(Fanconi anemia,FA)是一种常染色体退行性疾病,由于先天异常,患者出现进行性全血L细胞减少,易于发展为白血病和实体瘤,最常见为急性髓性白血病(AML)。精确估计FA的癌症发病风险有助于患者及医生做出更好的医疗决策。本文回顾性评估了FA患者罹患肿瘤的风险。
Fanconi anemia (FA) is an autosomal recessive disease that develops in patients with progressive whole blood L-cell depletion due to a congenital abnormality and is susceptible to leukemia and solid tumors, most commonly acute myeloid leukemia (AML ). Accurately estimating the risk of developing cancer in the FA can help patients and physicians make better medical decisions. This article retrospectively assessed the risk of developing tumors in FA patients.