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目的:探讨血清炎症因子白细胞介素18(L-18)及白细胞介素1β(L-1β)与妊娠期糖尿病(GDM)发病的关系。方法:选择2006～2009年在该院门诊产检孕妇90例,分为3组,GDM胰岛素抵抗组30例,GDM非胰岛素抵抗组30例,对照组30例。检测血清空腹血糖(FBG)、空腹胰岛素(FINS);酶联免疫吸附试验(ELISA)方法检测血清L-18、L-1β。结果:GDM胰岛素抵抗组L-18为(243.16±64.23)ng/L,L-1β为(157.49±29.60)ng/L;非胰岛素抵抗组血清L-18为(174.27±66.78)ng/L,L-1β为(83.58±28.20)ng/L,均明显高于对照组〔(121.44±41.15)ng/L,(45.24±25.64)ng/L〕,差异有统计学意义(P<0.05);GDM胰岛素抵抗组血清L-18、L-1β明显高于GDM非胰岛素抵抗组(P<0.05)。GDM组血清L-18、L-1β与胰岛素抵抗指数Homa IR呈显著正相关(P<0.05)。结论:炎症因子L-18、L-1β在妊娠期糖尿病患者血清中明显升高,慢性炎症可能与妊娠期糖尿病的发病有关。
Objective: To investigate the relationship between serum inflammatory factors interleukin 18 (18-IL-18) and interleukin-1β (L-1β) and gestational diabetes mellitus (GDM). Methods: From 2006 to 2009, 90 outpatients were randomly divided into three groups: 30 in GDM insulin resistance group, 30 in GDM non-insulin resistance group and 30 in control group. Serum fasting blood glucose (FBG) and fasting insulin (FINS) were measured. Serum levels of L-18 and L-1β were detected by enzyme-linked immunosorbent assay (ELISA) Results: The L-18 of GDM insulin resistance group was (243.16 ± 64.23) ng / L and L-1β was (157.49 ± 29.60) ng / L, while the non-insulin resistance group was 174.27 ± 66.78 ng / L, (83.58 ± 28.20) ng / L, which were significantly higher than those in the control group (121.44 ± 41.15 ng / L, 45.24 ± 25.64 ng / L, P <0.05) Serum levels of L-18 and L-1β in GDM insulin resistance group were significantly higher than those in GDM non-insulin resistance group (P <0.05). Serum levels of L-18 and L-1β in GDM group were positively correlated with Homa IR (P <0.05). Conclusion: The inflammatory cytokines L-18 and L-1β are significantly elevated in the serum of gestational diabetes mellitus patients. Chronic inflammation may be related to the pathogenesis of gestational diabetes mellitus.