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目的:探讨山楂叶总黄酮(hawthorn leaves flavonoids,HLF)对高脂血症大鼠抗氧化作用的影响及与PON1活性的关系。方法:采用维生素D3加脂肪乳剂造成大鼠高脂血症模型,并检测血清超氧化物歧化酶(SOD)、丙二醛(MDA)及对氧磷酶(PON1)含量。结果:1.HLF可明显降低血清总胆固醇(TC)、甘油三脂(TG)和低密度脂蛋白胆固醇(LDL-C)含量,提高高密度脂蛋白胆固醇(HDL-C)/TC比值。2.HLF可增强SOD及PON1活性,抑制高脂饮食所升高的MDA水平。结论:HLF具有较强的抗氧化作用,其抗AS作用可能与其增加PON1表达、继而增强HDL抗氧化能力有关。
Objective: To investigate the effect of hawthorn leaves flavonoids (HLF) on the anti-oxidation of hyperlipidemic rats and its relationship with PON1 activity. Methods: The model of hyperlipidemia was induced by using vitamin D3 and fat emulsion. The levels of serum superoxide dismutase (SOD), malondialdehyde (MDA) and paraoxonase (PON1) were measured. Results: 1.HLF can significantly reduce the content of serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) and increase the ratio of high-density lipoprotein cholesterol (HDL-C) 2.HLF can enhance the activity of SOD and PON1 and inhibit the elevated MDA level in high-fat diet. CONCLUSION: HLF has a strong anti-oxidant effect, and its anti-AS effect may be related to increasing PON1 expression and subsequently enhancing anti-oxidative capacity of HDL.