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目的了解河北省2010—2012年期间15岁以下儿童格林-巴利综合征(GBS)发病率及流行病学特征。方法对河北省2010—2012年报告的15岁以下所有GBS病例进行个案调查,并对其发病情况进行描述流行病学分析和统计分析。结果 2010—2012年河北省报告15岁以下GBS病例183例,年平均发病率0.49/10万。病例分布全省11个市,以散发为主。发病呈现夏秋季高发特点,0~5岁儿童发病占57.3%,男女性别比为1.77∶1,麻痹前有36.1%病例曾出现发热,27.3%的病例残留麻痹。结论该省低龄儿童发病较高,夏秋季节高发,发病与疫苗接种无时间关联性,建议进一步加强GBS的基础发病率研究,进一步深入探讨其发病病因,为防治GBS提供参考。
Objective To understand the incidence and epidemiological characteristics of Guillain-Barre syndrome (GBS) in children under 15 years of age in Hebei Province from 2010 to 2012. Methods All cases of GBS reported under the age of 15 in China reported from 2010 to 2012 in Hebei Province were investigated by case study and the epidemiological analysis and statistical analysis of their incidence were carried out. Results In 2010-2012, Hebei Province reported 183 GBS cases under the age of 15 with an average annual incidence of 0.49 / 100 000. The distribution of 11 provinces in the province, mainly to the distribution. The incidence of high incidence of summer and autumn showed characteristics of children aged 0 to 5 accounted for 57.3%, male to female ratio was 1.77: 1, before paralysis, 36.1% of cases had fever, 27.3% of cases residual paralysis. Conclusion The young children in the province have higher incidence, high incidence in summer and autumn, and no correlation between incidence and vaccination. It is suggested to further study the basic incidence of GBS and further explore its etiology and provide a reference for the prevention and treatment of GBS.