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目的通过观察病毒性脑炎、细菌性脑膜炎及结核性脑膜炎患儿脑脊液肝细胞生长因子(HGF)水平变化,探讨其是否可以作为一个鉴别诊断的生化指标,为临床疾病的诊断提供依据。方法选择临床确诊病毒性脑炎30例、细菌性脑膜炎21例、结核性脑膜炎19例及对照组24例,采用酶联免疫吸附试验双抗体夹心法检测各组患儿脑脊液HGF水平。同时将HGF水平分别与脑脊液中白细胞计数和蛋白定量进行直线相关分析,观察脑脊液中HGF水平与脑脊液中白细胞计数和蛋白定量的关系。结果细菌性脑膜炎组、结核性脑膜炎组脑脊液HGF水平高于病毒性脑炎组和对照组,结核性脑膜炎组高于细菌性脑膜炎组患儿,细菌性脑膜炎组、结核性脑膜炎组及病毒性脑炎组与对照组患儿比较均有显著性差异(Pa<0.05),病毒性脑炎组与对照组患儿比较差异无统计学意义(P>0.05)。结论 HGF有可能成为鉴别细菌性脑膜炎、结核性脑膜炎及病毒性脑炎的指标之一。
Objective To observe the changes of cerebrospinal fluid hepatocyte growth factor (HGF) in children with viral encephalitis, bacterial meningitis and tuberculous meningitis, and to explore whether it can be used as a biochemical marker in differential diagnosis to provide basis for the diagnosis of clinical diseases. Methods Thirty cases of clinically diagnosed viral encephalitis, 21 cases of bacterial meningitis, 19 cases of tuberculous meningitis and 24 cases of control group were selected. HGF level in cerebrospinal fluid in each group was detected by enzyme-linked immunosorbent assay (ELISA). At the same time, the level of HGF and cerebrospinal fluid in white blood cell count and protein quantitative linear correlation analysis to observe the cerebrospinal fluid HGF levels and cerebrospinal fluid leukocyte count and protein quantitative relationship. Results The levels of HGF in cerebrospinal fluid in bacterial meningitis group and tuberculous meningitis group were higher than those in viral encephalitis group and control group. The incidence rates of tuberculous meningitis group were higher than those in bacterial meningitis group, bacterial meningitis group, tuberculous meningitis group, There was significant difference between the inflammatory group and the viral encephalitis group and the control group (P <0.05). There was no significant difference between the viral encephalitis group and the control group (P> 0.05). Conclusion HGF may be one of the indicators to distinguish bacterial meningitis, tuberculous meningitis and viral encephalitis.