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大量的实验室资料及流行病学资料表明非甾体类消炎药 (NSAIDs)对消化道肿瘤具有防治作用。其可能的机制如下 :(1 )抑制环氧合酶 - 2 (COX - 2 )的活性和前列腺素 (PGs)的合成 ;(2 )诱导细胞凋亡 ;(3 )其它机制如 :抑制转录因子核因子ΚB(NuclearFactor-ΚB ,NF -ΚB)、抑制幽门螺杆菌、改变细胞周期及激活三叶肽等。近年来 ,开发出了更为安全有效的新型非甾体类消炎药 ,有望应用于临床消化道肿瘤的化学预防及化学治疗。
A large number of laboratory data and epidemiological data show that non-steroidal anti-inflammatory drugs (NSAIDs) on the gastrointestinal cancer prevention and treatment. Its possible mechanisms are as follows: (1) inhibition of cyclooxygenase - 2 (COX - 2) activity and synthesis of prostaglandins (PGs); (2) induction of apoptosis; (3) other mechanisms such as inhibition of transcription factors Nuclear factor KB (NF-κB), inhibit H. pylori, change cell cycle and activate trefoil peptide. In recent years, we have developed a new type of non-steroidal anti-inflammatory drug that is safer and more effective. It is expected to be used in chemical prevention and chemotherapy of clinical gastrointestinal tumors.