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目的:观察分析阿奇霉素临床应用中的不良反应/不良事件。方法:将自2013年1月1日至2015年12月31日间在我院使用各类阿奇霉素药物进行治疗的出现不良反应/不良事件的89例患者为研究对象,整理患者的多项,并对评价指标进行统计分析。结果:89例患者的不良反应主要为肠胃道(46.07%)、皮肤过敏(29.21%)、神经系统(17.98%)、其它消化系统以及呼吸系统;89例患者共发生一起尖端扭转综合征型室速不良事件;各年龄段中以少儿年龄段发生最多(77.53%);使用的药物中注射液发生比例最高(48.31%),后依次为分散片(30.33%)、胶囊(14.61%)、干混悬剂(6.75%)。结论:使用阿奇霉素出现的不良反应/不良事件主要与使用药物的种类和年龄有关,而不良反应主要体现在肠胃道、皮肤过敏、神经系统,所以在使用阿奇霉素时应根据这些因素综合考虑,以降低不良反应/不良事件的发生率。
Objective: To observe and analyze adverse reactions and adverse events in the clinical application of azithromycin. METHODS: A total of 89 patients with adverse reactions / adverse events who were treated with azithromycin in our hospital from January 1, 2013 to December 31, 2015 were selected as study subjects, The evaluation index for statistical analysis. Results: The adverse reactions in 89 patients were mainly gastrointestinal tract (46.07%), skin allergy (29.21%), nervous system (17.98%), other digestive system and respiratory system. A total of 89 patients developed a torsades de pointes syndrome (77.53%) in all age groups. The highest incidence of injection (48.31%) occurred in the drugs used, followed by dispersible tablets (30.33%), capsules (14.61%), Suspension (6.75%). Conclusions: Adverse reactions / adverse events associated with azithromycin are mainly related to the type and age of the drug used. Adverse reactions are mainly manifested in the gastrointestinal tract, skin allergies, and nervous system. Therefore, azithromycin should be considered in consideration of these factors to reduce Adverse reactions / incidence of adverse events.