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目的:分析临床应用氟喹诺酮类药物治疗的不良反应。方法:选取我院共480例应用氟喹诺酮类药物而出现不良反应的患者。患者应用氧氟沙星、加替沙星、莫西沙星、诺氟沙星这四种药物进行治疗。结果:服用不同药物患者出现的不良反应发生率相比,差异有统计学意义(P<0.05)。口服和静脉注射药物用药方式所产生的不良反应发生率相对比,差异有统计学意义(P<0.05)。服用不同药物患者出现的不良反应的临床表现相比有差异性,有统计学意义P<0.05)。随着年龄的增长,患者的恢复时间越长,各个年龄段之间,相对比有统计学意义(P<0.05)。结论:在临床中应用氟喹诺酮类药物进行治疗,要根据患者的病情和体质情况选择正确的用药方式和剂量,对患者进行密切观察,从而降低不良反应的发生。
Objective: To analyze the adverse reactions of clinical treatment with fluoroquinolones. Methods: A total of 480 patients with fluoroquinolones in our hospital were selected for adverse reactions. Patients with ofloxacin, gatifloxacin, moxifloxacin, norfloxacin these four drugs for treatment. Results: Compared with the incidence of adverse reactions in patients taking different drugs, the difference was statistically significant (P <0.05). There was a significant difference in the incidence of adverse reactions between oral and intravenous drug administration (P <0.05). The clinical manifestations of adverse reactions in patients taking different drugs were significantly different (P <0.05). With the increase of age, the recovery time of patients was longer, and the relative proportions of all age groups were statistically significant (P <0.05). Conclusion: In the clinical application of fluoroquinolones for treatment, according to the patient’s condition and constitution to choose the correct mode of administration and dose, the patients were closely observed, thereby reducing the incidence of adverse reactions.