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慢性粒细胞白血病急变是患者死亡最主要原因,文献报道干扰素治疗慢性粒细胞白血病（下称慢粒）可减少急变发生,有利于患者长期存活。我科对1989～1991年应用干扰素（α-IFN）治疗缓解后的5例慢粒患者,进行血液学随访追踪,并与同期应用马利兰治疗者比较,发现干扰素治疗患者血液学稳定,至今无1例发生急变,明显优于应用马利兰治疗的患者。
The rapid change of chronic myelogenous leukemia is the main cause of death in patients. It is reported in the literature that interferon treatment of chronic myelogenous leukemia (hereinafter referred to as chronic granulocyte leukemia) can reduce abrupt changes and is beneficial to long-term survival of patients. In our department, we conducted follow-up hematological studies on 5 patients with chronic granulopathy after remission from 1989 to 1991 treated with interferon alpha (α-IFN), and compared with patients treated with Malaria in the same period, we found that patients treated with interferon have stable hematology. No sudden change occurred in 1 case, which was significantly better than that of patients treated with Marlyn.