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In addition to serving as molecular chaperones,heat shock proteins (HSPs) have been implicated inautoimmune diseases,antigen presentation and tumor immunity.Extensive work in the last 10 years has alsosuggested that HSPs such as Hsp60,Hsp70,Hsp90 and gp96,may be potent activators of the innate immunesystem capable of inducing the production of pro-inflammatory cytokines by the monocyte-macrophage system,and the activation and maturation of dendritic cells via the Toll-like receptor 2 and 4 signal transductionpathways.However,recent evidence suggests that the reported cytokine effects of HSPs may be a result of thecontaminating bacterial cell-wall products.This concise review summarizes the current controversy over therole of HSPs in innate immunity.Cellular & Molecular Immunology.2004;1(4):274-279.
In addition to serving as molecular chaperones, heat shock proteins (HSPs) have been implicated in autoimmune diseases, antigen presentation and tumor immunity. Extensive work in the last 10 years has alsosuggested that HSPs such as Hsp60, Hsp70, Hsp90 and gp96, may be potent activators of the innate immunesystem capable of inducing the production of pro-inflammatory cytokines by the monocyte-macrophage system, and the activation and maturation of dendritic cells via the Toll-like receptor 2 and 4 signal transduction pathways. Recent evidence suggests that the reported cytokine effects of HSPs may be a result of thecontaminating bacterial cell-wall products. This concise review summarizes the current controversy over the course of HSPs in innate immunity. Cellular & Molecular Immunology. 2004; 1 (4): 274-279.