论文部分内容阅读
目的观察胃癌、贲门癌患者外周血T淋巴细胞核仁形成区嗜银蛋白(AgNORs)的含量变化与正常人对照的关系,分析AgNORs的变化与胃癌、贲门癌的诊断和疗效关系的意义。方法使用北京凯隆仪器公司生产的KL-肿瘤免疫图像分析系统对胃癌、贲门癌患者外周血AgNORs进行分析,观察32例胃癌、贲门癌患者的T淋巴细胞核仁面积与细胞核面积之比值(I.S%)大小,并与28例正常人检测结果对比。结果28例正常人I.S%平均值为8.15%,而观察组32例平均值为5.25%,经统计学处理后,P<0.01;而且I.S%值的变化在化疗前后差异有统计学意义,但性别、年龄及肿瘤类型之间差异无统计学意义。结论外周血AgNORs的检测可以作为胃癌、贲门癌的诊断和预后指标之一。
Objective To observe the changes of AgNORs in peripheral blood T lymphocytes of patients with gastric cancer and cardia cancer and the correlation between the changes of AgNORs and the diagnosis and curative effect of gastric cancer and cardia cancer. Methods AgNORs in peripheral blood from patients with gastric cancer and cardia cancer were analyzed by KL-Tumor Immunoassay System. The ratio of nucleolar area to nucleus area was observed in 32 patients with gastric cancer and cardia cancer (IS% ) Size, and with 28 normal people test results contrast. Results The mean IS% of 28 normal subjects was 8.15%, while the average of 32 cases in observation group was 5.25%. After statistical treatment, P <0.01; and the change of IS% was statistically significant before and after chemotherapy, There was no significant difference in gender, age and tumor type. Conclusion The detection of peripheral blood AgNORs can be used as one of the indicators of diagnosis and prognosis of gastric cancer and cardiac cancer.