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UL-FS49是目前减慢心率作用和选择性最强的药物之一,它可降低清醒犬的心率,而无降压作用。本文研究它对血液动力学、局部心肌血流量以及心肌功能的作用。对经成巴比妥钠(25mg/kg)和巴比妥钠(200mg/kg)处理的麻醉犬,应用7F双压换能器导管由左颈动脉分别置入主动脉和左室,通过左室压力脉冲电子微分法获得左室总收缩性指数(正向峰值dp/dt)。并分离左回旋支(LCX),放置电磁流量探头测定冠脉血流量。测定左前降支和LCX冠脉灌注区域的心肌节段功能(节段缩短百分比)。应用
UL-FS49 is one of the most slow-acting and selective drugs that slow down the heart rate of awake dogs without antihypertensive effect. This article studies its effects on hemodynamics, local myocardial blood flow, and myocardial function. For anesthetized dogs treated with pentobarbital sodium (25 mg / kg) and sodium pentobarbital (200 mg / kg), a 7F dual-pressure transducer catheter was placed into the aorta and left ventricle from the left carotid artery, Room pressure pulse electron differential method to obtain total systolic left ventricular index (positive peak dp / dt). The left circumflex artery (LCX) was isolated and the coronary flow was measured by placing a magnetic flow probe. Myocardial segmental function (percentage reduction of segments) was measured in the areas of left anterior descending and LCX coronary perfusion. application